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Welcome to ENACT.

We’re a psychedelic science research laboratory at Yale. Scroll down to learn about our studies and the science behind them.

ENACT is a Yale research lab advancing the science of psychedelic medicine. As the first laboratory within the Yale Program for Psychedelic Science, we study whether medicines like psilocybin can help where other options have fallen short — for conditions like depression, PTSD, and OCD. Scroll down to see our studies, our team, and how the research works.

See all studies
Three ways in

Take part, refer, or support the research.

ENACT is a clinical research laboratory. Whichever way you arrive, here is what each door leads to.

Join a study

“I would like to take part.”

Our clinical trials are open to adults who match what each study is looking for. Taking part is voluntary: it starts with a short intake call, then screening, and you can withdraw at any time. If a study has not opened yet, you can ask to hear when it does.

Book an Intake Call

Refer a Patient

“I’m a clinician referring a patient.”

Clinicians and providers can refer a patient to a study that is recruiting. Tell us about yourself, the patient, and the study you have in mind; our team looks at whether the study is a fit and follows up with you. A referral does not commit your patient to taking part.

Refer a Patient

Support the research

“I would like to support the research.”

Three ways, for money, time, or attention: fund a study — gifts made through Yale University directly support ENACT’s research; collaborate with the lab — partnerships start with a conversation; or stay updated — an occasional letter on which studies are recruiting and what has published.

See the ways to support
What we do

One laboratory, five ways knowledge becomes practice.

Clinical trials

Investigator-initiated and industry-sponsored studies — from first-in-population trials to Phase 3 registration studies — under FDA oversight.

Psychedelic Medicine Fellowship

Preparing the next generation of clinician-scientists in psychedelic medicine.

Express interest

Facilitation training

Training therapists to support psychedelic-assisted care with skill and humility.

Ask about training

Media & public engagement

Bringing the science into public conversation, carefully and in plain language.

Media inquiries

YPPS ecosystem & partnerships

The operational foundation that lets specialized research divisions incubate and grow.

Science shaped by lived experience — knowledge enacted into meaningful change.

More about ENACT
Why we do it

Science shaped by lived experience.

Most clinical trials leave out people with multiple diagnoses — but that is not how mental illness works in practice. Our research is designed around real-world patients, with people supported before, during, and after every session.

Every study is conducted under FDA oversight at Yale School of Medicine, with care teams of psychiatrists, physicians, and licensed therapists.

More about ENACT
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What to expect in a clinical trial

Every clinical trial follows its own protocol. Here is how each one begins.

1

Fill out a form

A short intake form: your name, contact details, and the study or condition you’re interested in. Submitting it asks us for an intake call — nothing more.

Book an Intake Call
2

Assessment

A brief 15–30 minute call with our team about your interest, your health history, and which study may be a fit. It’s a first look at whether a study is a fit, with no obligation.

3

Screening & preparation

Psychiatric and medical evaluation to confirm you meet the study’s criteria, then preparatory sessions with the study team so you know exactly what the study involves.

4

Joining the study

The study team goes through the consent form with you before anything begins. From here, every study follows its own protocol — sessions, assessments, and follow-ups differ by study, and your study team walks you through yours.

Thinking about writing to us? What to expect if you inquire.

Explore
TeamMeet the investigators and coordinators named on our studies.Meet the teamResearch & TrialsExplore our ongoing clinical trials and research initiatives.See the studiesJoin or referWays to take part, and referral pathways.Start the process

Sign up for an intake call.

Take the first step into science shaped by lived experience. A brief conversation, no obligation — our team will guide you through the process.